ALK- rearrangement in non-small-cell lung cancer (NSCLC)
نویسندگان
چکیده
منابع مشابه
ALK‐rearrangement in non‐small‐cell lung cancer (NSCLC)
The ALK gene encodes a transmembrane tyrosine kinase receptor. ALK is physiologically expressed in the nervous system during embryogenesis, but its expression decreases postnatally. ALK first emerged in the field of oncology in 1994 when it was identified to fuse to NPM1 in anaplastic large-cell lymphoma. Since then, ALK has been associated with other types of cancers, including non-small-cell ...
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Journal of Thoracic Oncology • Volume 7, Number 9, September 2012 The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) gene fusion occurs in 2% to 7% of non–small-cell lung cancer (NSCLC) cases and is typically identified by Vysis ALK Break-Apart fluorescent in situ hybridization (FISH) assay. Tumors expressing this fusion respond to treatment using crizoti...
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ژورنال
عنوان ژورنال: Thoracic Cancer
سال: 2018
ISSN: 1759-7706
DOI: 10.1111/1759-7714.12613